What is Rabies Post Exposure Prophylaxis (RPEP)?
RPEP is the only effective treatment known to prevent rabies. It is a combination of a rabies vaccine and Immunoglobulin given over a series of weeks.
I was bitten or scratched by an animal. How can I get RPEP?
It is important to see your doctor or health care provider if you have been bitten or scratched by an animal. The health care provider can assess if you have been potentially exposed to the rabies virus and whether RPEP is needed. The health care provider will contact Ottawa Public Health to order RPEP.
I was bitten on scratched by an animal, but I think I had rabies vaccine in the past. Do I need more doses?
If you have been vaccinated against rabies in the past and have been newly exposed to an animal with rabies you must receive additional doses of vaccine to be protected. Discuss this with your healthcare provider to be sure that you are protected. It is important to keep your vaccine records up to date to make sure a proper assessment can be done.
How is Ottawa Public Health (OPH) involved with RPEP?
- OPH is contacted by a health care provider who has assessed a patient with a potential exposure to the rabies virus after a bite or contact with an animal's saliva. OPH will deliver RPEP to the health care provider. Following the rabies vaccine schedule from the Canadian Immunization Guide is very important. OPH will call you to make sure that you receive the right doses on the right days. See the table in the "How is RPEP given to an exposed person?" section for more details.
- In 2023, OPH, working alongside local health care providers, coordinated the distribution of RPEP doses to 214 individuals with suspected rabies exposure.
[1] Ministry of Health and Long-term Care (MOHLTC), integrated Public Health Information System (iPHIS), extracted by Ottawa Public Health, September 6, 2024.
How is RPEP given to an exposed person?
Your health care provider will administer RPEP by providing two types of medications. One is rabies immunoglobulin (RabIg). RabIg is given with a needle to provide antibodies to fight the rabies virus immediately. RabIg is given into and around the wound or the site of exposure if the bite or scratch is no longer visible. If not all RabIg can be given into the site of exposure, the remainder is given in an arm or leg that is not being used for the rabies vaccine. The second medication is a vaccine against rabies that is given in four or five doses on different days and on a very specific schedule to stimulate your immune system to make its own antibodies against rabies.
It is always preferred that you begin RPEP on the same day that the bite or exposure to rabies occurred. On the day that you begin RPEP, one dose of vaccine and the RabIg are administered. Additional doses of vaccine are given on days 3, 7, 14 and sometimes on day 28. Your health care provider and OPH will determine if a fifth dose on day 28 is required.
RPEP schedule as per the Canadian Immunization Guide*
| Day of RPEP administration |
RPEP required |
| Day 0 (first dose, given as soon as possible after first bite, scratch or saliva exposure) |
RabIg at wound site + Rabies Vaccine (2 different body sites) |
| Day 3 |
Rabies vaccine |
| Day 7 |
Rabies vaccine |
| Day 14 |
Rabies vaccine |
| Day 28 (only required in certain cases) |
Rabies vaccine |
*Canadian Immunization Schedule for RPEP
Do I have to pay for RPEP?
All doses of RPEP are provided free of charge by OPH to Ottawa residents who are considered to be potentially exposed to the rabies virus.
I can't make it to a scheduled appointment on one of the days in the schedule. Can I skip a dose or reschedule?
No. If you cannot make an appointment, it is very important that you call OPH and your health care provider right away. In order to be effective, the schedule for RPEP MUST be followed exactly and all doses must be given.
It is important that RPEP is started as soon as possible after the bite or scratch for the best possible protection. RPEP is effective in preventing rabies disease if given correctly.